PT  - JOURNAL ARTICLE
AU  - Al Saihati, Hajir A.
AU  - Rabaan, Ali A.
TI  - Cellular resistance mechanisms in cancer and the new approaches to overcome resistance mechanisms chemotherapy
AID  - 10.15537/smj.2023.44.4.20220600
DP  - 2023 Apr 01
TA  - Saudi Medical Journal
PG  - 329--344
VI  - 44
IP  - 4
4099  - http://smj.org.sa/content/44/4/329.short
4100  - http://smj.org.sa/content/44/4/329.full
SO  - Saudi Med J2023 Apr 01; 44
AB  - Despite major advancements in cancer healing approaches over the last few decades, chemotherapy remains the most popular malignancy treatment. Chemotherapeutic drugs are classified into many kinds based on their mechanism of action. Multidrug resistance (MDR) is responsible for approximately 90% of fatalities in malignancy cases treated with standard chemotherapeutics or innovative targeted medicines. Many innovative prospective anti-cancer medicines displayed high anti-cancer efficacy in a single application. However, combining them with other medications improves cancer treatment efficacy. This supports the belief that a combination of drugs is significantly more effective than a single medicine. Due to the intricacy of MDR processes and the diversity of tumor illnesses, there will rarely be a single medicine that can be utilized to treat all types of cancer. Finding new medications that can reverse MDR in malignancy cells will augment efficacy of chemotherapeutic agents and allow us to treat cancers that are now incurable.