PT  - JOURNAL ARTICLE
AU  - Basuliman, Abdullah S.
AU  - Malabarey, Mohammed A.
AU  - Abousamak, Fahad W.
AU  - Alyousef, Bader Y.
AU  - Alrabea, Saleh S.
AU  - Alshabibi, Rakan A.
AU  - Aseri, Zohair A. Al
TI  - Predictive value of triglycerides to high density lipoprotein ratio in patients with first attack of acute coronary syndrome
AID  - 10.15537/smj.2023.44.4.20220928
DP  - 2023 Apr 01
TA  - Saudi Medical Journal
PG  - 379--384
VI  - 44
IP  - 4
4099  - http://smj.org.sa/content/44/4/379.short
4100  - http://smj.org.sa/content/44/4/379.full
SO  - Saudi Med J2023 Apr 01; 44
AB  - Objectives: To identify patients who are at risk for a first cardiovascular event, mitigate the risk, and institute early intervention. The triglyceride to high-density lipoprotein-C (TG/HDL-C) ratio has been found to be a very useful biomarker for directing treatment and prevention therapy.Methods: This retrospective cross-sectional study included adult patients (aged >18 years) experiencing first-time acute coronary syndrome (ACS). We examined all patient databases for a definite diagnosis of angina, non-ST segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). Lipid profiles were obtained prior to or at the time of admission.Results: A total of 265 patients were included in the study (mean age 57.83 ± 11.4 years) and 79.2% were men. Male gender, presence of diabetes, raised total cholesterol, raised low-density lipoprotein (LDL), and raised troponin level on admission were significantly positively correlated with STEMI (p=0.004, p=0.001, p<0.001, and p<0.001), whereas TG/HDL-C ratio was significantly negatively correlated with STEMI (p=0.048), while there was no significant results with NSTEMI (p=0.264) and angina (p=0.326). Total cholesterol and raised low-density lipoprotein (LDL) were significantly positively correlated with NSTEMI (p=0.013 and p=0.024).Conclusion: Patients with first-time ACS may not have an increased TG/HDL-C ratio. High LDL levels had the most significant association with an ACS event, along with total cholesterol and diabetes. Further research is needed on a larger scale to determine the association of TG/HDL-C ratio with ACS and differentiate the different types of ACS events according to their clinical and laboratory characteristics.