PT  - JOURNAL ARTICLE
AU  - Alshaikh, Nahla A.
AU  - Abdelwahab, Siddig I.
AU  - Habibullah, Mahmoud M.
AU  - Jerah, Ahmed A.
AU  - Bakri, Mohammed A.
AU  - Kaabi, Yahia A.
TI  - Frequency of the rs2015 (T>G) and rs2241703 (G>A) polymorphisms in the miRNA-SIRT2 gene in type 2 diabetes mellitus in Saudi Arabia
AID  - 10.15537/smj.2023.44.4.20220863
DP  - 2023 Apr 01
TA  - Saudi Medical Journal
PG  - 363--367
VI  - 44
IP  - 4
4099  - http://smj.org.sa/content/44/4/363.short
4100  - http://smj.org.sa/content/44/4/363.full
SO  - Saudi Med J2023 Apr 01; 44
AB  - Objectives: To investigate the prevalence of rs2015 (T>G) and rs2241703 (G>A) polymorphisms in the miRNA-SIRT2 gene in Saudi Arabia and their possible associations with type 2 diabetes mellitus (T2DM).Methods: Blood samples were collected from 428 participants from Jazan University Hospital, Jazan, Saudi Arabia between September 2021 and June 2022 and subjected to TaqMan single-nucleotide polymorphisms (SNP) genotyping assay for rs241703 (G>A) and rs2015 (G>T). Genotype frequencies were determined in control (n=217).Results: The A allele of rs2241703 was undetected in our population, and all samples carried the GG genotype. The rs2015 SNP frequency was 29.4% for GG, 45.6% for GT, and 24% for TT. However, logistic regression analysis of the dominant inheritance model showed no association between the T allele and T2DM calculated odds ratio [OR]=0.80, 95% confidence interval=0.53 to 1.20, p=0.301).Conclusion: Although rs2241703 SNP of Sirtuins 2 is not present, rs2015 SNP is highly prevalent in Saudi Arabia, but no direct link was identified with T2DM.