@article {Monagel498, author = {Dania A. Monagel and Aletani Tala and Alghamdi Arwa and Banjar Sereen and Hakeem Ilana and Hannef Deena and Ahmed Omaima and Elimam Naglla}, title = {Clinical and pathological characteristics of extra-cranial germ cell tumors}, volume = {44}, number = {5}, pages = {498--499}, year = {2023}, doi = {10.15537/smj.2023.44.5.20230070}, publisher = {Saudi Medical Journal}, abstract = {Objectives: To investigate the clinical and pathological characteristics of extracranial germ cell tumors (GCTs) in children aged 0{\textendash}168 months treated at the National Guard Hospital, Jeddah, Saudi Arabia from 1990 to 2020.Methods: In this retrospective analysis, the data for all cases of GCTs were collected from 1990 to 2020. Statistical analyses were carried out using JMP software. The data was divided into 4 main categories: demographics, pathological/clinical features, recurrence, treatment and outcome.Results: The study included 50 patients, with a mean age at diagnosis of 56.52 months. The median follow-up duration was 30 months. Most tumors were in the gonads, and among the extragonadal tumors, the sacro-coccyx was the most frequent site of the disease.The most common histological subtype of GCTs is yolk sac tumor, accounting for 28\% of cases. Of the 50 patients, 46\% received chemotherapy, and 54\% underwent surgery without chemotherapy. Ten (20\%) patients experienced recurrence after treatment. At the last follow-up, 96\% of the patients were alive, and only 2 of the patients died due to advanced disease.Conclusion: Our findings were comparable to international data, but improvement in surveillance is required for long-term survivors.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/44/5/498}, eprint = {https://smj.org.sa/content/44/5/498.full.pdf}, journal = {Saudi Medical Journal} }