PT  - JOURNAL ARTICLE
AU  - Monagel, Dania A.
AU  - Tala, Aletani
AU  - Arwa, Alghamdi
AU  - Sereen, Banjar
AU  - Ilana, Hakeem
AU  - Deena, Hannef
AU  - Omaima, Ahmed
AU  - Naglla, Elimam
TI  - Clinical and pathological characteristics of extra-cranial germ cell tumors
AID  - 10.15537/smj.2023.44.5.20230070
DP  - 2023 May 01
TA  - Saudi Medical Journal
PG  - 498--499
VI  - 44
IP  - 5
4099  - http://smj.org.sa/content/44/5/498.short
4100  - http://smj.org.sa/content/44/5/498.full
SO  - Saudi Med J2023 May 01; 44
AB  - Objectives: To investigate the clinical and pathological characteristics of extracranial germ cell tumors (GCTs) in children aged 0–168 months treated at the National Guard Hospital, Jeddah, Saudi Arabia from 1990 to 2020.Methods: In this retrospective analysis, the data for all cases of GCTs were collected from 1990 to 2020. Statistical analyses were carried out using JMP software. The data was divided into 4 main categories: demographics, pathological/clinical features, recurrence, treatment and outcome.Results: The study included 50 patients, with a mean age at diagnosis of 56.52 months. The median follow-up duration was 30 months. Most tumors were in the gonads, and among the extragonadal tumors, the sacro-coccyx was the most frequent site of the disease.The most common histological subtype of GCTs is yolk sac tumor, accounting for 28% of cases. Of the 50 patients, 46% received chemotherapy, and 54% underwent surgery without chemotherapy. Ten (20%) patients experienced recurrence after treatment. At the last follow-up, 96% of the patients were alive, and only 2 of the patients died due to advanced disease.Conclusion: Our findings were comparable to international data, but improvement in surveillance is required for long-term survivors.