RT Journal Article
SR Electronic
T1 Clinical and pathological characteristics of extra-cranial germ cell tumors
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 498
OP 499
DO 10.15537/smj.2023.44.5.20230070
VO 44
IS 5
A1 Monagel, Dania A.
A1 Tala, Aletani
A1 Arwa, Alghamdi
A1 Sereen, Banjar
A1 Ilana, Hakeem
A1 Deena, Hannef
A1 Omaima, Ahmed
A1 Naglla, Elimam
YR 2023
UL http://smj.org.sa/content/44/5/498.abstract
AB Objectives: To investigate the clinical and pathological characteristics of extracranial germ cell tumors (GCTs) in children aged 0–168 months treated at the National Guard Hospital, Jeddah, Saudi Arabia from 1990 to 2020.Methods: In this retrospective analysis, the data for all cases of GCTs were collected from 1990 to 2020. Statistical analyses were carried out using JMP software. The data was divided into 4 main categories: demographics, pathological/clinical features, recurrence, treatment and outcome.Results: The study included 50 patients, with a mean age at diagnosis of 56.52 months. The median follow-up duration was 30 months. Most tumors were in the gonads, and among the extragonadal tumors, the sacro-coccyx was the most frequent site of the disease.The most common histological subtype of GCTs is yolk sac tumor, accounting for 28% of cases. Of the 50 patients, 46% received chemotherapy, and 54% underwent surgery without chemotherapy. Ten (20%) patients experienced recurrence after treatment. At the last follow-up, 96% of the patients were alive, and only 2 of the patients died due to advanced disease.Conclusion: Our findings were comparable to international data, but improvement in surveillance is required for long-term survivors.