PT  - JOURNAL ARTICLE
AU  - Bahaidarah, Saud
AU  - Alzahrani, Fatma
AU  - Alshinqiti, Mohammed
AU  - Moria, Nader
AU  - Alahwal, Fahad
AU  - Naghi, Khalid
AU  - Abdulfattah, Ammar
AU  - Alharbi, Mohammed
AU  - Abdelmohsen, Gaser
TI  - Factors influencing blood pressure fluctuation in pediatric patients with sickle cell disease in Saudi Arabia
AID  - 10.15537/smj.2023.44.7.20230251
DP  - 2023 Jul 01
TA  - Saudi Medical Journal
PG  - 655--660
VI  - 44
IP  - 7
4099  - http://smj.org.sa/content/44/7/655.short
4100  - http://smj.org.sa/content/44/7/655.full
SO  - Saudi Med J2023 Jul 01; 44
AB  - Objectives: To investigate changes in blood pressure (BP) among pediatric patients with sickle cell disease (SCD) and determine the variables that might influence these changes.Methods: A total of 100 pediatric patients with SCD who followed up in the pediatric outpatient clinic were recruited for this retrospective cohort study. Clinical data included anthropometric measures, average systolic and diastolic BP recorded during multiple follow-up visits, hemoglobin (Hb) level, serum creatinine, and hemoglobin S percentage. Blood pressure measurements were categorized according to the guidelines of the American Academy of Pediatrics (AAP, 2017).Results: In this cohort, 68% of the patients had normal systolic BP, 13% had elevated systolic BP, 17% had stage 1 hypertension (HTN), while only 2% reported stage 2 HTN. Patients who were overweight had relatively high systolic BP compared to patients who were underweight (p=0.034) or had normal weight (p=0.023). The average systolic BP significantly correlates with body mass index (r= 0.377, p<0.001) and serum creatinine (r=0.369, p<0.001).Conclusion: Pediatric overweight SCD patients exhibited higher average systolic BP than those underweight or normal weight. Body mass index and serum creatinine significantly influenced the average systolic BP more than the Hb level or Hb S percentage.