PT  - JOURNAL ARTICLE
AU  - Mıstanoglu Ozatag, Duru
AU  - Korkmaz, Pınar
AU  - Keskin, Havva
AU  - Koçak, Havva
TI  - The usability of neopterin in determining disease course in COVID-19
AID  - 10.15537/smj.2023.44.8.20230365
DP  - 2023 Aug 01
TA  - Saudi Medical Journal
PG  - 767--772
VI  - 44
IP  - 8
4099  - http://smj.org.sa/content/44/8/767.short
4100  - http://smj.org.sa/content/44/8/767.full
SO  - Saudi Med J2023 Aug 01; 44
AB  - Objectives: To investigate the usability of neopterin in demonstrating the progression of COVID-19. As a result of uncontrolled activation of COVID-19 monocytes and macrophages, IFN gamma increases and the resulting inflammatory response causes organ damage. IFN released from T cells causes an increase in gamma neopterin levels. Therefore, measurement of neopterin levels can be used to indicate immune system activation and disease progression.Methods: The study was carried out prospectively in two different centers. The patients were divided into two groups (mild-moderate and severe) and clinical, laboratory, imaging findings and neopterin levels at hospitalization were compared.Results: 100 patients were included in our study, 41 of these patients were male. Forty-six patients were identified as severe COVID-19. C-reactive protein, lymphocyte count, fibrinogen, D dimers, lactate dehydrogenase, procalcitonin, troponin and neopterin levels were significant in indicating disease severity. (p<0.05). In ROC analysis, 0.642 for neopterin, 0.698 C-reactive protein, 0.331 lymphocyte count, 0.679 procalcitonin, 0.633 fibrinogen, 0.667 D dimers, 0.655 troponin and 0.706 lactate dehydrogenase were detected and these values were significant.Conclusion: In our study, neopterin was detected as an important indicator in determining the course of COVID-19.