PT - JOURNAL ARTICLE AU - Fan, Haidi AU - Liu, Yanqiu AU - Zhang, Xin AU - Sun, Jian AU - Lin, Ning TI - Clinical significance of elevated soluble T-cell immunoglobulin and mucin domain 1 and soluble P-selectin in individuals with obstructive sleep apnea-hypopnea syndrome AID - 10.15537/smj.2023.44.11.20230452 DP - 2023 Nov 01 TA - Saudi Medical Journal PG - 1113--1119 VI - 44 IP - 11 4099 - http://smj.org.sa/content/44/11/1113.short 4100 - http://smj.org.sa/content/44/11/1113.full SO - Saudi Med J2023 Nov 01; 44 AB - Objectives: To assess the serum concentrations of soluble T-cell immunoglobulin and mucin domain 1 (sTIM-1) and soluble P-selectin (sP-selectin) in individuals who had obstructive sleep apnea-hypopnea syndrome (OSAHS).Methods: Between December 2020 and November 2022, 134 participants from the Sleep Monitoring Center of the Branch Hospital of Huai’an First People’s Hospital, Jiangsu, China, engaged in this cross-sectional study. Participants were categorized as mild OSAHS (n=19), moderate OSAHS (n=22), severe OSAHS (n=57), and non-OSAHS (n=36) groups. Serum levels of sTIM-1, sP-selectin, and interleukin (IL)-6, as well as baseline clinical characteristics and polysomnography outcomes were assessed in each participant.Results: Compared to the non-OSAHS group, sTIM-1 and sP-selectin levels were considerably elevated in people who had moderate or severe OSAHS (all p<0.05), but there were no notable changes between those who had mild OSAHS and non-OSAHS participants (p>0.05). The sTIM-1 and sP-selectin levels showed positive associations with the apnea-hypopnea index, body mass index (BMI), and IL-6 levels (all p<0.001). While elevated sTIM-1 was independently related to OSAHS (odds ratio [OR]=1.134, p=0.001), sP-selectin was not associated with OSAHS after adjusting for BMI (OR=1.013, p=0.467).Conclusion: People with moderate or severe OSAHS had higher serum sTIM-1 and sP-selectin levels, and elevated sTIM-1 is an independently related factor for OSAHS.