PT  - JOURNAL ARTICLE
AU  - Wang, Qian
AU  - Hao, Jia
AU  - Jiang, Wenjun
AU  - Tan, Qiang
TI  - Enhanced external counterpulsation increases coronary flow reserve in coronary microvascular disease
AID  - 10.15537/smj.2023.44.12.20230427
DP  - 2023 Dec 01
TA  - Saudi Medical Journal
PG  - 1277--1282
VI  - 44
IP  - 12
4099  - http://smj.org.sa/content/44/12/1277.short
4100  - http://smj.org.sa/content/44/12/1277.full
SO  - Saudi Med J2023 Dec 01; 44
AB  - Objectives: To investigates the outcomes of enhanced external counterpulsation (EECP) among coronary microvascular disease (CMD) patients.Methods: Coronary microvascular disease patients were separated into the EECP (n=41) and control cohorts (n=42). Prior to and following the 4-week EECP program, coronary flow reserve (CFR) was recorded using transthoracic Doppler echocardiography. The serum endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) contents were analyzed by ELISA. Quality of life (QoL) was assessed by the Seattle Angina Questionnaire (SAQ) and the Canadian Cardiovascular Society (CCS) angina class.Results: After four weeks, CFR was substantially enhanced in the EECP versus control cohort (p<0.05). Endothelin-1 was strongly diminished whereas eNOS was considerably upregulated in the EECP cohort. EECP also enhanced patients’ SAQ scores and decreased the CCS angina class.Conclusion: Enhanced external counterpulsation may improve CFR and enhance the CMD patient QoL.