PT  - JOURNAL ARTICLE
AU  - Alqahtani, Bashaer
AU  - Daghestani, Maha
AU  - Omair, Mohammed A.
AU  - Alenzi, Fahidah
AU  - Alhamad, Esam H.
AU  - Tashkandy, Yusra
AU  - Othman, Nashwa
AU  - Warsy, Arjumand
AU  - Halwani, Rabih
TI  - Single nucleotide polymorphisms in cytokine genes and their association with primary Sjögren’s syndrome in Saudi patients
AID  - 10.15537/smj.2023.44.12.20230490
DP  - 2023 Dec 01
TA  - Saudi Medical Journal
PG  - 1232--1239
VI  - 44
IP  - 12
4099  - http://smj.org.sa/content/44/12/1232.short
4100  - http://smj.org.sa/content/44/12/1232.full
SO  - Saudi Med J2023 Dec 01; 44
AB  - Objectives: To determine the allelic frequencies and effects of genotypic variations in cytokine gene polymorphisms in a Saudi Arabian population.Methods: This cross-sectional study involved 41 patients with Primary Sjögren’s syndrome (pSS) and 71 healthy controls between October 2018 and May 2019. Single nucleotide polymorphisms genotyping was performed using the SEQUENOM MassARRAY® System, targeting nine polymorphisms in different cytokine genes. Chi-square tests were used to compare the patients and controls.Results: The interleukin-1 beta (IL-1β) rs1143627 CT (control, 52.7%; patients, 21.2%) and TT + CT (p= 0.003; p=0.033) genotypes were less frequent in patients with pSS than in healthy controls. The C allele in rs10488631 in the interferon regulatory factor 5 (IRF5) gene and the A allele in rs12583006 in the B-cell activating factor (BAFF) gene were associated with an increased risk of pSS development in the patient group.Conclusion: The CT genotype at −31 (rs1143627) in the IL-1β gene was not associated with a high risk of pSS development in the Saudi population, in contrast to what has been verified in other ethnicities. However, the C allele in rs10488631 in IRF-5 and the A allele in rs12583006 in BAFF were associated.