PT  - JOURNAL ARTICLE
AU  - Almutairi, Nasser
AU  - Alshathri, Alanoud
AU  - Alshareef, Waleed
AU  - Sindi, Abdullah
AU  - Aljasser, Abdullah
AU  - Alammar, Ahmed
TI  - Clinical evaluation of pediatric patients with recurrent respiratory papillomatosis.
AID  - 10.15537/smj.2024.45.2.20230529
DP  - 2024 Feb 01
TA  - Saudi Medical Journal
PG  - 205--210
VI  - 45
IP  - 2
4099  - http://smj.org.sa/content/45/2/205.short
4100  - http://smj.org.sa/content/45/2/205.full
SO  - Saudi Med J2024 Feb 01; 45
AB  - Objectives: To study the clinical evaluation of recurrent respiratory papillomatosis (RRP) patients and the factors associated with the improvement in the Derkay’s score as a measure of disease severity.Methods: A retrospective cohort that included all juvenile RRP patients who were admitted to King Abdulaziz University Hospital, Riyadh, Saudi Arabia, between September 2015 and June 2022 and underwent surgical debulking.Results: A total of 16 patients were eligible to join our study. Among them, 7 patients were males. Hoarseness of voice was the most frequent symptom. The median period of the follow-up was 56 months. Complete remission was achieved in 31.3%. The univariate linear regression model revealed that the cidofovir-treated patients had a significant reduction in the change value of Derkay’s score compared to those without treatment (regression coefficient= -5.83, 95% confidence interval [CI]: [-11.5 to -0.143], p=0.045). Also, the increased first Derkay’s score decreased the change value and subsequently increased the improvement chance of the disease (regression coefficient= -0.424, 95% CI: [-0.764 to -0.083], p=0.018). However, in the multivariate regression model, both variables showed non-significant results.Conclusion: cidofovir treatment and higher Derkay’s scores affected the disease improvement.