PT  - JOURNAL ARTICLE
AU  - Alturaiki, Wael
TI  - Immunomodulatory effects of BAFF and APRIL cytokines in post-pulmonary infection lung cancer
AID  - 10.15537/smj.2024.45.3.20230873
DP  - 2024 Mar 01
TA  - Saudi Medical Journal
PG  - 223--229
VI  - 45
IP  - 3
4099  - http://smj.org.sa/content/45/3/223.short
4100  - http://smj.org.sa/content/45/3/223.full
SO  - Saudi Med J2024 Mar 01; 45
AB  - Lung cancer is a complicated and challenging disease and is one of the most common causes of cancer-related mortality worldwide. Within the lung microenvironment, specific cytokines, including the B cell activation factor (BAFF) and the A proliferation-inducing ligand (APRIL), are produce by various cells, notably airway epithelial cells, in response allergic inflammation or pulmonary infection. These cytokines play a critical role in maintaining local immune responses and fostering the survival of immune cells. The BAFF and APRIL system have been connected in a range of malignancies and have shown their potential in inducing drug resistance and promoting cancer progression. This review highlights recent studies on the involvement of BAFF and APRIL in various cancers, focusing mainly on their role in lung cancer, and discusses the possibility of these molecules in contributing to drug resistance and cancer progression following pulmonary infection. We suggest consideration the targeting BAFF and APRIL or their respective receptors as promising novel therapies for effective treatment of lung cancer, especially post pulmonary infection. However, it remains important to conduct further investigations to fully elucidate the precise mechanisms underlying how the BAFF and APRIL systems enhance cancer survival and drug resistance subsequent pulmonary infections.