PT  - JOURNAL ARTICLE
AU  - Nurlaila, Ika
AU  - Pambudi, Sabar
TI  - The evolvement of breast cancer therapies
AID  - 10.15537/smj.2024.45.4.20230492
DP  - 2024 Apr 01
TA  - Saudi Medical Journal
PG  - 331--340
VI  - 45
IP  - 4
4099  - http://smj.org.sa/content/45/4/331.short
4100  - http://smj.org.sa/content/45/4/331.full
SO  - Saudi Med J2024 Apr 01; 45
AB  - Although, from a therapeutic standpoint, breast cancer (BC) is considerably well-characterized, it still leaves puzzling spots. The Her-2+/PR+/ER+ BC can benefit from the mainstays of anticancer therapy and immunotherapy and overall have a better prognosis. Triple-negative BC, due to the concomitant absence of Her-2/PR/ER receptors, is more challenging and necessitates different strategies. It has been learned that the mainstay anti-BC therapies were initially designed to demolish as many cancer cells as they possibly could. However, the number of reports on the adverse effects of these mainstay therapies has recently been increasing. It underpins efforts to reshape such therapies into much better and safer forms over time. Moreover, some current findings on the molecular markers, which are target-potential, have also shifted the paradigm from radical-to-local-yet-precise-approach to meet the need for a therapy platform that is less cytotoxic to normal cells yet efficiently kills cancer cells.