RT Journal Article SR Electronic T1 The evolvement of breast cancer therapies JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 331 OP 340 DO 10.15537/smj.2024.45.4.20230492 VO 45 IS 4 A1 Nurlaila, Ika A1 Pambudi, Sabar YR 2024 UL http://smj.org.sa/content/45/4/331.abstract AB Although, from a therapeutic standpoint, breast cancer (BC) is considerably well-characterized, it still leaves puzzling spots. The Her-2+/PR+/ER+ BC can benefit from the mainstays of anticancer therapy and immunotherapy and overall have a better prognosis. Triple-negative BC, due to the concomitant absence of Her-2/PR/ER receptors, is more challenging and necessitates different strategies. It has been learned that the mainstay anti-BC therapies were initially designed to demolish as many cancer cells as they possibly could. However, the number of reports on the adverse effects of these mainstay therapies has recently been increasing. It underpins efforts to reshape such therapies into much better and safer forms over time. Moreover, some current findings on the molecular markers, which are target-potential, have also shifted the paradigm from radical-to-local-yet-precise-approach to meet the need for a therapy platform that is less cytotoxic to normal cells yet efficiently kills cancer cells.