PT  - JOURNAL ARTICLE
AU  - Huang, Jing
AU  - Shen, Wei
AU  - Wu, Fan
AU  - Mao, Jian
AU  - Liu, Ling
AU  - Chang, Yanmei
AU  - Zhang, Rong
AU  - Ye, Xiuzhen
AU  - Qiu, Yinping
AU  - Ma, Li
AU  - Cheng, Rui
AU  - Wu, Hui
AU  - Chen, Dongmei
AU  - Chen, Ling
AU  - Xu, Ping
AU  - Mei, Hua
AU  - Wang, Sannan
AU  - Xu, Falin
AU  - Ju, Rong
AU  - Zheng, Zhi
AU  - Lin, Xinzhu
AU  - Tong, Xiaomei
TI  - Risk factors for severe bronchopulmonary dysplasia in a Chinese cohort of very preterm infants
AID  - 10.15537/smj.2024.45.4.20230741
DP  - 2024 Apr 01
TA  - Saudi Medical Journal
PG  - 369--378
VI  - 45
IP  - 4
4099  - http://smj.org.sa/content/45/4/369.short
4100  - http://smj.org.sa/content/45/4/369.full
SO  - Saudi Med J2024 Apr 01; 45
AB  - Objectives: To examine the risk factors for severe bronchopulmonary dysplasia (BPD) in a cohort of very preterm infants (VPIs) in China, as BPD is common among VPIs and associated with a high mortality rate.Methods: In this multicenter retrospective study, medical records from infants with BPD born at gestation age (GA) of <32 weeks with birth weight (BW) of <1,500 grams (g) in 7 regions of China were included. The cohort was stratified into different BPD severity groups based on their fraction of inspired oxygen requirement at a modified GA of 36 weeks or post discharge. Risk factors were identified using logistic regression analysis.Results: A significant inverse correlation was revealed between BPD severity and both GA and BW (p<0.001). Independent risk factors for severe BPD (sBPD) were identified as invasive mechanical ventilation (≥7d), multiple blood transfusion (≥3), nosocomial infection (NI), hemodynamically significant patent ductus arteriosus (hsPDA), delayed initiation of enteral nutrition, and longer time to achieve total caloric intake of 110 kcal/kg. Conversely, administration of antenatal steroids was associated with reduced risk of sBPD.Conclusion: Our study not only reaffirmed the established risk factors of low GA and BW for sBPD in VPIs, but also identified additional, potentially modifiable risk factors. Further research is warranted to explore whether intervention in these modifiable factors might reduce the risk of sBPD.Clinical Trial Reg. No.: ChiCTR1900023418