RT Journal Article
SR Electronic
T1 Risk factors for severe bronchopulmonary dysplasia in a Chinese cohort of very preterm infants
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 369
OP 378
DO 10.15537/smj.2024.45.4.20230741
VO 45
IS 4
A1 Huang, Jing
A1 Shen, Wei
A1 Wu, Fan
A1 Mao, Jian
A1 Liu, Ling
A1 Chang, Yanmei
A1 Zhang, Rong
A1 Ye, Xiuzhen
A1 Qiu, Yinping
A1 Ma, Li
A1 Cheng, Rui
A1 Wu, Hui
A1 Chen, Dongmei
A1 Chen, Ling
A1 Xu, Ping
A1 Mei, Hua
A1 Wang, Sannan
A1 Xu, Falin
A1 Ju, Rong
A1 Zheng, Zhi
A1 Lin, Xinzhu
A1 Tong, Xiaomei
YR 2024
UL http://smj.org.sa/content/45/4/369.abstract
AB Objectives: To examine the risk factors for severe bronchopulmonary dysplasia (BPD) in a cohort of very preterm infants (VPIs) in China, as BPD is common among VPIs and associated with a high mortality rate.Methods: In this multicenter retrospective study, medical records from infants with BPD born at gestation age (GA) of <32 weeks with birth weight (BW) of <1,500 grams (g) in 7 regions of China were included. The cohort was stratified into different BPD severity groups based on their fraction of inspired oxygen requirement at a modified GA of 36 weeks or post discharge. Risk factors were identified using logistic regression analysis.Results: A significant inverse correlation was revealed between BPD severity and both GA and BW (p<0.001). Independent risk factors for severe BPD (sBPD) were identified as invasive mechanical ventilation (≥7d), multiple blood transfusion (≥3), nosocomial infection (NI), hemodynamically significant patent ductus arteriosus (hsPDA), delayed initiation of enteral nutrition, and longer time to achieve total caloric intake of 110 kcal/kg. Conversely, administration of antenatal steroids was associated with reduced risk of sBPD.Conclusion: Our study not only reaffirmed the established risk factors of low GA and BW for sBPD in VPIs, but also identified additional, potentially modifiable risk factors. Further research is warranted to explore whether intervention in these modifiable factors might reduce the risk of sBPD.Clinical Trial Reg. No.: ChiCTR1900023418