RT Journal Article
SR Electronic
T1 The association of the hepatitis B virus infection and diffuse large B-cell lymphoma
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 490
OP 494
DO 10.15537/smj.2024.45.5.20231024
VO 45
IS 5
A1 Yu, Guodong
A1 Han, Jijing
A1 Xu, Jianmei
YR 2024
UL http://smj.org.sa/content/45/5/490.abstract
AB Objectives: To investigate the basic characteristics of patients with diffuse large B-cell lymphoma (DLBCL) and whether hepatitis B surface antigen positive (HBsAg [+]) affects the survival of patients with DLBCL.Methods: The study was carried out at Affiliated Hospital of Hebei University, Baoding, China, including 602 DLBCL cases from January 2011 to December 2021. We analyzed patients’ general clinical data and applied multivariate and univariate Cox analyses to assess the factors influencing their survival times.Results: The HBsAg(+) and HBsAg(-) groups comprised 154 (25.6%) and 448 (74.4%) of the 602 cases, respectively. HBsAg(+) cases tended to be later-stage (III–IV) with higher international prognostic index (IPI) points (3–5) and a greater tendency toward B symptoms, impaired liver function, and recurrence than HBsAg(-) cases (all p<0.05). After follow-up, 194 (32.2%) patients died. The median overall survival (OS) and 5-year OS rates in the HBsAg(+) and HBsAg(-) groups were 16.5 months (42%) and 35 months (63%), respectively. Cox analyses indicated that HBsAg(+) affected the prognosis of DLBCL cases (HR=1.46, 95%CI=1.07-1.99, p=0.017).Conclusion: The HBsAg(+) seems to be an independent hazard factor for the worse prognosis of DLBCL patients; hence, a focus on these patients in clinic is required.