RT Journal Article
SR Electronic
T1 Prevalence of CEA, CA 125, and CA 15-3 serum tumour markers in different regions of Saudi Arabia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 565
OP 571
DO 10.15537/smj.2024.45.6.20230878
VO 45
IS 6
A1 Ashi, Abrar
A1 Al-Hajeili, Marwan
A1 Almaghrabi, Sarah
A1 Al-Maghrabi, Jaudah
A1 Trabulsi, Nora
A1 Alghuraibi, Shmoukh
A1 Alsiary, Rawaih
A1 Alrayes, Nuha
YR 2024
UL http://smj.org.sa/content/45/6/565.abstract
AB Objectives: To study the prevalence of tumor marker (TM) carcinoembryonic antigen (CEA), cancer antigen 125 (CA 125), and cancer antigen 15-3 (CA 15-3) levels in the Saudi population, based on gender, age, and demographic region, and whether the patients were referred by a hospital or self-referred.Methods: Retrospective analysis was carried out on 7,019 samples gathered from the Western, Northern, Central, Southern, and Eastern regions of Saudi Arabia between 2021-2022. The TMs were categorized into normal and abnormal levels, according to the reference ranges. Statistical analysis was carried out to assess the relations between variants (age groups, gender, and demographic regions) using the Chi-square test, and their correlations were assessed using Spearman’s test.Results: Among all patients, CEA, CA 125, and CA 15-3 levels were found to be significantly correlated with age (p=0.0001). The CEA and CA 15-3 levels increased in both males and females with age. The CA 125 was shown to have an abnormally increased level in males with age.Conclusion: Increased levels of CEA, CA 125, and CA 15-3 TMs in the study population were significantly correlated with age. The CEA and CA 15-3 levels were within the normal range, while CA 125 levels were above the normal range in the older male population. These results suggest that the utilization of such TMs is age dependent and would have validity if applied with other parameters.