PT  - JOURNAL ARTICLE
AU  - Uyar, Cemile
AU  - Yıldız, Emel
AU  - Genç, Özlem
AU  - Ak, Öznur
AU  - Koçak, Emel
AU  - Alkan, Sevil
AU  - Balcı, Canan
AU  - Korkmaz, Pınar
AU  - Özatağ, Duru Mıstanoğlu
AU  - Aslan, Halil
TI  - Evaluation of candidemia risk factors and <em>Candida</em> species distribution in intensive care units among patients with and without COVID-19
AID  - 10.15537/smj.2024.45.6.20240102
DP  - 2024 Jun 01
TA  - Saudi Medical Journal
PG  - 606--616
VI  - 45
IP  - 6
4099  - http://smj.org.sa/content/45/6/606.short
4100  - http://smj.org.sa/content/45/6/606.full
SO  - Saudi Med J2024 Jun 01; 45
AB  - Objectives: To assess the risk variables related to the types of candidemia for each patient, who was admitted into the intensive care unit regardless of the patient with or without complete diagnosis of COVID-19, during the period of March 2019 to December 2022.Methods: The evaluation comparison of demographic and clinical data of COVID-19 positive and negative patients with candidemia confirmed in blood, 113 cases were assessed. Variables such as gender, age, age of hospitalization, history of hospitalization, concurrently infection, The acute physiology and chronic health evaluation-II scores, comorbidity checking, intubation, central venous catheter use, parenteral nutrition use, steroid use, antibiotic use, lymphopenia, and laboratory variables were evaluated. Candida species distribution, antifungal susceptibility in blood culture were determined.Results: Coronavirus disease-19 was present in 62.8% of cases confirmed candidemia, and these cases were significantly different from COVID-19 negative cases. Significance was found in more intubation, central venous catheter use, parenteral nutrition, and steroid therapy in Group 2. There was no significance with species distribution and associated infection. In total, COVID-19 positive had higher hemoglobin, aspartate aminotransferase, alanine transaminase, and white blood cell levels, which may be associated with the possibility of revealing and controlling candidemia.Conclusion: Candida albicans and Candida Parapsilosis (C. parapsilosis) are the species seen in infected COVID-19 patients, while C. parapsilosis and Candida tropicalis are found in non-COVID-19 ones. Risk factors were intubation, parenteral nutrition, central venous catheter, and steroid in the COVID-19 group.