RT Journal Article
SR Electronic
T1 Serological markers of transfusion transmissible infections and ABO blood groups in Najran, Saudi Arabia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 667
OP 674
DO 10.15537/smj.2024.45.7.20240338
VO 45
IS 7
A1 Alshehri, Ahmad A.
A1 Adebayo Irekeola, Ahmad
A1 Merae Alshahrani, Mohammed
A1 Mohammed Abdul, Khaja Shameem
A1 Ahmed Asiri, Saeed
A1 Aboluluy, Banan F.
A1 Abdullah Al Awadh, Ahmed
A1 Hassan Alhasaniah, Abdulaziz
A1 Abdullah Almazni, Ibrahim
A1 Alshamrani, Saleh A.
A1 Alshahrani, Abdullah J.
A1 Saif, Ahmad M.
A1 Elnoubi, Osman AE.
A1 Hakami, Abdulrahim R.
A1 Abdulaziz Othman, Abdulrazzag
A1 Almohi, Mansor H.
YR 2024
UL http://smj.org.sa/content/45/7/667.abstract
AB Objectives: To ascertain the prevalence of transfusion transmissible infections (TTIs) across diverse donor groups in the Najran province. Additionally, to establish a potential association between the development of TTI and the donors’ blood group, as determined by the ABO/Rh blood grouping system.Methods: Blood donation data of 4120 donors, spanning from January to December 2020, were retrospectively reviewed. The blood were screened for TTI markers, including hepatitis B surface antigen (HBsAg), anti-hepatitis B core (anti-HBc), anti-hepatitis C virus (anti-HCV), anti-human immunodeficiency viruses 1 and 2 (anti-HIV1&2), anti-human T-lymphotropic virus types 1 and 2 (anti-HTLV-1&2), and syphilis antigen.Results: Positive TTI markers were detected in 10.9% of the donors. The most detected TTI marker was anti-HBc (8.9%), followed by HBsAg (0.7%). Other markers were individually detected in <1% of the donors. Anti-HBc-positive was significantly elevated among non-Saudi blood donors. There was an association between age groups and anti-HCV (p=0.002), anti-HTLV (p=0.004) and syphilis antigen (p=0.02) markers positivity. The AB positive blood group exhibited the most positivity for TTI markers, followed by O positive blood group. Similarly, association was found between ABO group and HBsAg (p=0.01), anti-HBc (p=0.001), and anti-HCV (p<0.001) markers positivity.Conclusion: Emphasis on implementing robust screening measures for donated blood is underscored by this study. There is the need for future study to extensively evaluate TTI status to enhance our understanding of the trend in TTI.