RT Journal Article SR Electronic T1 Thrombocytopenia following iron repletion with ferrous gluconate JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 848 OP 850 DO 10.15537/smj.2024.45.8.20231003 VO 45 IS 8 A1 Al Saud, Aljoharah A. A1 AlRomaizan, Muneerah R. A1 Alkhunizan, Muath A. YR 2024 UL http://smj.org.sa/content/45/8/848.abstract AB Immune thrombocytopenia (ITP) is an autoimmune disorder marked by low platelet counts that puts patients at risk for spontaneous bleeding. A rare trigger for ITP is iron repletion, which has only been reported in a few cases. In this article, we present a unique case of a 54-year-old male with a history of recurrent ITP who experienced rapid thrombocytopenia following iron repletion with ferrous gluconate. Discontinuation of ferrous medications resulted in platelet counts returning to the normal baseline. Following more than 30 years of the patient’s clinical timeline, this case demonstrates the chronic nature of ITP and the complexity of its causes. Further studies are needed to determine the prevalence of iron repletion-induced thrombocytopenia and its underlying mechanisms.