PT  - JOURNAL ARTICLE
AU  - Obaid, Jamil M.
AU  - Saghir, Sultan A.
AU  - Al-Hroob, Amir M.
AU  - Mohammed, Shaima A.
AU  - Melhi, Ola’a A.
AU  - Alhomamy, Ashgan A.
AU  - Al-Qodaimi, Elham A.
TI  - Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances
AID  - 10.15537/smj.2024.45.10.20240308
DP  - 2024 Oct 01
TA  - Saudi Medical Journal
PG  - 1064--1070
VI  - 45
IP  - 10
4099  - http://smj.org.sa/content/45/10/1064.short
4100  - http://smj.org.sa/content/45/10/1064.full
SO  - Saudi Med J2024 Oct 01; 45
AB  - Objectives: To ascertain the prevalence of ABH antigen secretors and non-secretors among Yemenis. In addition to explore the factors that may affect the expression of the secretion phenotype.Methods: This cross-sectional study was carried out between May and September 2022 on 215 healthy Yemeni individuals at the International Malaysian University, Ibb, Yemen. The participants were tested for blood group antigen on their blood samples using standard test tube method using the suitable ABH antisera. Saliva was collected and tested for secretion using hemagglutination inhibition test with suitable A, B, and H antisera. Before collecting the blood samples, informed consent was obtained from each participant and complete data and history questionnaire were collected by the research team.Results: In general, 78.1% of Yemini participants were found to be secretor (80% men and 73.3% females). This percentage increased within O blood group (95%) and decreased within AB blood group (54%) individuals. Both O and AB blood groups showed statistically significant association with secretor trait. Also, it was noticed that age advance increases the expression of Se gene. In addition, the secretor state increased among Rh-negative people.Conclusion: The frequency of ABH secretors was 78.1% among Ibb province population in Yemen. Blood group O revealed the greatest frequency (95%), whereas blood group AB showed the lowest secretor frequency (54%). The secretor phenotype was highly expressed gradually with advance age then decline.