RT Journal Article
SR Electronic
T1 Hypothyroidism is a risk factor for transient ischemic attack
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 117
OP 123
DO 10.15537/smj.2025.46.2.20240508
VO 46
IS 2
A1 Li, Jian
A1 Liu, Hui
A1 Li, Yan
YR 2025
UL http://smj.org.sa/content/46/2/117.abstract
AB Objectives: To evaluate whether hypothyroidism is a risk factor for transient ischemic attack (TIA).Methods: We systematically searched Embase, PubMed, Cochrane, Vipers database, China Biomedical Literature Database, Wanfang Data, and China National Knowledge Infrastructure for studies assessing the association between hypothyroidism and TIA (publication cut-off in May 2024). Two researchers independently extracted the data based on inclusion and exclusion criteria. Meta-analysis was carried out using Review Manager 5.3 software.Results: A total of 7 studies (combined n=190248) were included. Hypothyroidism showed a significant association with TIA (risk ratio [RR]=1.43 [95% confidence interval [CI]: [1.29-1.57]). The association was significant in clinical hypothyroidism (RR=1.45 [95% CI: [1.31-1.62]) but not evident in subclinical hypothyroidism (RR=1.20 [95% CI: [0.90-1.61]). Sensitivity analysis confirmed the stability and reliability of the results from the 7 studies (Begg’s test z=1.2, p<0.01). No significant publication bias was detected in the meta-analysis.Conclusion: Hypothyroidism, particularly clinical hypothyroidism, may be an independent risk factor for TIA.PROSPERO No. ID: CRD42024552608