PT  - JOURNAL ARTICLE
AU  - Alosaimi, Sultan
AU  - Alqarni, Abdullah
AU  - Alkalifah, Turki
AU  - Aldaijy, Mansor
AU  - Alghamdi, Nawaf
AU  - Altalhah, Abdulltaif
AU  - Kazi, Ambreen
AU  - Alharbi, Waleed
TI  - Gender differences in patient-reported outcomes and cardiac symptoms in patients with acute coronary syndrome in Riyadh, Saudi Arabia
AID  - 10.15537/smj.2025.46.20240735
DP  - 2025 Apr 01
TA  - Saudi Medical Journal
PG  - 388--397
VI  - 46
IP  - 4
4099  - http://smj.org.sa/content/46/4/388.short
4100  - http://smj.org.sa/content/46/4/388.full
SO  - Saudi Med J2025 Apr 01; 46
AB  - Objectives: To measure the gender differences in patient-reported outcomes and cardiac symptoms in patients with acute coronary syndrome (ACS) at King Khalid University Hospital in Riyadh, Saudi Arabia.Methods: A cross-sectional study was conducted on 240 randomly selected ACS patients aged ≥18 years. Data were collected using validated questionnaires, including Patient-reported outcomes measures, the Rose Dyspnea Scale, Patient Health Questionnaire, and Seattle Angina Questionnaire. Multiple linear regression analysis was conducted to identify factors associated with quality of life (QoL).Results: The study included 60% males and 40% females. Females reported significantly lower global physical health scores (11.62 [±2.49] versus (vs) 13.68 [±2.68], p=0.00), higher dyspnea symptoms (2.61 [±1.41] vs 1.55 [±1.51], p=0.00), and more physical limitation (43.2 [±31.8] vs 55.19 [±33.96], p=0.02). Multiple linear regression analysis showed female gender was associated with a decline in physical health (-0.33 [-2.42, -1.00]), increased dyspnea symptoms (0.30 [0.55, 1.37]), higher depression scores (0.14 [0.004, 0.87]), a decline in SAQ physical activity [-0.19 (-23.68, -2.60)] and summary scores [-0.14 (-11.34, -.04)]. Older age and lower income were also significantly associated with poorer QoL outcomes.Conclusion: Female gender, advanced age, and lower income were associated with worse patient-reported outcomes in ACS patients. Healthcare providers should consider these disparities to improve management strategies and QoL in this population.