RT Journal Article
SR Electronic
T1 Renal histopathology spectrum in children with kidney diseases in Saudi Arabia, 1998-2017
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 369
OP 375
DO 10.15537/smj.2020.4.24999
VO 41
IS 4
A1 Khalid Alhasan
A1 Noura M. Aloudah
A1 Amaar A. Bakhit
A1 Yassin M. Alhamad
A1 Kechrid M. Chihabeddine
A1 Talal A. Alfaadhel
A1 Tariq E. Aljohani
A1 Hanadi M. Alhozali
A1 Abdulkareem O. Alsuwaida
YR 2020
UL http://smj.org.sa/content/41/4/369.abstract
AB Objectives: To identify the trends in the diagnostic frequency of glomerular disease subtypes by renal biopsy in children in Saudi Arabia over the last 20 years.Methods: In this retrospective observational study, we identified all patients aged <18 years for whom native kidney biopsy was performed between 1998 and 2017. The period during which biopsy was performed (1998-2004, 2005-2011, and 2012-2017) and the demographic information and their association with the prevalence of various glomerular disease subtypes were our primary outcomes.Results: A total of 326 cases with renal biopsy were analyzed; the mean age of participants being 11 years and 45.4% of them were girls. Unexpectedly, secondary glomerulonephritis accounted for 42.3% of the cases, and lupus nephritis was the most common cause noted in 20.7% of the cases. The minimal change and focal segmental glomerulosclerosis were the most common glomerulonephritis in 59% of the cases. The frequency of membranoproliferative glomerulonephritis and mesangioproliferative glomerulonephritis significantly decreased from 15% and 17% in the period prior to 2004 to 3.3% (p=0.003) and 1.7% in 2012-2017 (p<0.001).Conclusions: We found a considerable shift in the frequency of many glomerular disease subtypes in 1998-2017, which make clinical predication of the underlying etiology challenging for clinician. Renal biopsy still remains a critical diagnostic procedure for managing a considerable proportion of renal diseases.