PT  - JOURNAL ARTICLE
AU  - Mothanna K. AlRahabi
AU  - Hani M. Ghabbani
TI  - Clinical impact of bisphosphonates in root canal therapy
AID  - 10.15537/smj.2018.3.20923
DP  - 2018 Mar 01
TA  - Saudi Medical Journal
PG  - 232--238
VI  - 39
IP  - 3
4099  - http://smj.org.sa/content/39/3/232.short
4100  - http://smj.org.sa/content/39/3/232.full
SO  - Saudi Med J2018 Mar 01; 39
AB  - Bisphosphonates are stable structural analogs of pyrophosphate, which suppress the activity of osteoclasts, leading to decreased bone resorption. They are essential medications in the treatment of osteoporosis. Osteonecrosis of the jaw is a serious adverse effect of bisphosphonate therapy. The prevalence of bisphosphonate-related osteonecrosis of the jaw varies from 0% to 28%, and it can be triggered by dental extraction and trauma. Root canal therapy can delay, or even eliminate, the need for tooth extraction, and therefore, may reduce the risk of bisphosphonate-related osteonecrosis of the jaw. We suggest that this might be the best treatment for teeth with pulpal and/or periapical disease.