RT Journal Article
SR Electronic
T1 Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 495
OP 499
DO 10.15537/smj.2018.5.22111
VO 39
IS 5
A1 Parlak, Ebru S.
A1 Alisik, Murat
A1 Hezer, Habibe
A1 Karalezli, Aysegul
A1 Hasanoglu, Hatice C.
A1 Erel, Ozcan
YR 2018
UL http://smj.org.sa/content/39/5/495.abstract
AB Objectives To compare dynamic thiol/disulfide homeostasis between patients with community-acquired pneumonia (CAP) and healthy controls.Methods This prospective, case-control study was conducted in the Department of Pulmonary Diseases, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey, between August 2016 and August 2017. In total, 50 hospitalized patients with CAP and 35 healthy individuals were enrolled. Patients with comorbidities and smokers were excluded. The thiol/disulfide state was evaluated in each group. Thiol levels (native/total) and % polymorhonuclear leukocytes and C-reactive protein levels association were evaluated in patients with CAP.Results There was no significant difference between the CAP and control groups in age or gender (both, p>0.05). The disulfide (SS) levels were similar between the 2 groups (p=0.148). The total thiol (TT) and native thiol (SH) levels were significantly lower (all, p=0.001) and the SS/TT levels were significantly higher (p=0.019) in the CAP group compared with the controls.Conclusions This study showed that the oxidant/antioxidant ratio was shifted to the oxidative side in CAP patients. An abnormal thiol/disulfide state may be an important factor in the pathogenesis and monitoring the treatment response. The thiol resources may use for treatment in CAP and may positively affect the prognosis.