PT  - JOURNAL ARTICLE
AU  - Fawzia E. Alotaibi
TI  - Fatal case of cerebral aspergilloma complicated by ventriculitis and bacteremia due to <em>Salmonella</em> species in a sickle cell disease patient
AID  - 10.15537/smj.2018.9.22821
DP  - 2018 Sep 01
TA  - Saudi Medical Journal
PG  - 935--939
VI  - 39
IP  - 9
4099  - http://smj.org.sa/content/39/9/935.short
4100  - http://smj.org.sa/content/39/9/935.full
SO  - Saudi Med J2018 Sep 01; 39
AB  - To describe a fatal case of invasive Aspergillus flavus sinusitis in a 43-year old female with sickle cell disease (SCD) complicated by intracerebral aspergilloma and invasive Salmonella infection. Cerebral aspergilloma carries a very high mortality rate. The patient developed post-craniotomy intracerebral hemorrhage at the site of biopsy, Salmonella species sepsis and ventriculitis. She presented with a 2-month history of headache, dizziness, personality and behavioral changes, and vomiting. Initial clinical evaluation raised the suspicion of brain tumor. Brain magnetic resonance imaging revealed a left frontal, thick-walled ring-enhancing lesion with extensive surrounding edema suggestive of a neoplastic lesion, or a contiguous inflammatory or infectious process from the skull base. Despite early diagnosis and appropriate antifungal and surgical management, she eventually died from severe infection and respiratory arrest. In conclusion, invasive aspergillosis should be included in the differential diagnosis of SCD patients with central nervous system (CNS) lesions.