TY - JOUR T1 - Effect of preoperative hydromorphone in patients undergoing laparoscopic radical gastrectomy JF - Saudi Medical Journal JO - Saudi Med J SP - 1023 LP - 1027 DO - 10.15537/smj.2018.10.22852 VL - 39 IS - 10 AU - Jinguo Wang AU - Na Wang AU - Honglan Zhou AU - Yuanyuan Wang Y1 - 2018/10/01 UR - http://smj.org.sa/content/39/10/1023.abstract N2 - Objectives: To determine the efficacy of preemptive hydromorphone for laparoscopic radical gastrectomy.Methods: The present prospective and double-blinded study was performed in the The First Hospital, Jilin University, Changchun, China, between July 2017 and April 2018. Fifty patients scheduled for laparoscopic radical, gastrectomy were equally randomized into 2 groups, which were administrated different drugs 10 minutes before surgery. Group P (the preemptive hydromorphone group) was administrated 2 mg hydromorphone (2 mL), and Group C (the control group) was administrated 2 mL normal saline intravenously. A standardized general anesthesia were conducted. Blood pressure and heart rate, postoperative morphine consumption, pain intensity, sedation status, and side effects were recorded.Results: Group C had larger intraoperative hemodynamic changes, higher postoperative visual analogue scale score, more morphine consumption and lower overall satisfaction degree than Group P. No difference was found between the 2 groups in sedation status and adverse effects.Conclusion: Preoperative 2 mg hydromorphone could reduce intraoperative changes of blood pressure and heart rate, postoperative pain intensity, and morphine consumption without an increase of adverse effects. ER -