PT  - JOURNAL ARTICLE
AU  - Erturk, Ismail
AU  - Saglam, Kenan
AU  - Elasan, Sadi
AU  - Aykan, Musa B.
AU  - Acar, Ramazan
AU  - Yesildal, Fatih
AU  - Aydin, Fevzi N.
AU  - Ozgurtas, Taner
TI  - Evaluation of the effects of different treatment modalities on angiogenesis in heart failure patients with reduced/mid-range ejection fraction via VEGF and sVEGFR-1
AID  - 10.15537/smj.2018.10.22946
DP  - 2018 Oct 01
TA  - Saudi Medical Journal
PG  - 1028--1034
VI  - 39
IP  - 10
4099  - http://smj.org.sa/content/39/10/1028.short
4100  - http://smj.org.sa/content/39/10/1028.full
SO  - Saudi Med J2018 Oct 01; 39
AB  - Objectives: To investigate the clinical significance of VEGF, sVEGFR-1 in heart failure reduced ejection fraction (HFrEF) and heart failure mid-range ejection fraction (HFmrEF) patients.Methods: A total of 104 people consisting of HFrEF and HFmrEF patients (n=54) and healthy (n=50) subjects were included in this comparative cross-sectional study. The study took place in Gulhane Training and Research Hospital, Ankara, Turkey, between 2011 and 2013. Serum VEGF, sVEGFR-1, plasma pro-BNP analysis and transthoracic echocardiography were performed.Results: The average sVEGFR-1 level of the HFrEF and HFmrEF patients was significantly higher than the control group (0.185±0.122; 0.141±0.120; p=0.013). The average sVEGFR-1 level of the HFrEF and HFmrEF patients using beta-blocker was significantly higher than the HFrEF and HFmrEF patients not using it (p=0.015). There was a significant and positive correlation between sVEGFR-1 and N-terminal pro-brain natriuretic peptide (pro-BNP) levels in the group with HF (r=0.211, p=0.044).Conclusion: It increases awareness about the role of sVEGFR-1 in HFrEF anf HFmrEF patients and the need for further studies. Beta-blocker may have a negative effect on angiogenesis in HFrEF and HFmrEF via increasing sVEGFR-1 levels. Additionally, Pro-BNP may contribute to inhibiting angiogenesis by increasing sVEGFR-1 levels and sVEGFR-1 may be an important biomarker in HFrEF and HFmrEF.