RT Journal Article SR Electronic T1 Effects of Ramadan fasting on moderate to severe chronic kidney disease JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 48 OP 52 DO 10.15537/smj.2017.1.17566 VO 38 IS 1 A1 Amaar A. Bakhit A1 Amr M. Kurdi A1 Junaid J. Wadera A1 Abdulkareem O. Alsuwaida YR 2017 UL http://smj.org.sa/content/38/1/48.abstract AB Objectives: To examin the effect of Ramadan fasting on worsening of renal function (WRF).Method: This was a single-arm prospective observational study including 65 patients with stage 3 or higher chronic kidney disease (CKD). By definition, WRF was considered to have occurred when serum creatinine levels increased by 0.3 mg/dL (26.5 µmol/l) from baseline during or within 3 months after Ramadan. The study was conducted in the Nephrology Clinic of King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia during the month of Ramadan 1436 AH (Hijiri), which corresponded to June 18-July 17, 2015.Results: This study included 65 adults with a mean age of 53 years. Overall, 33% of patients developed WRF. In the multivariate analysis, more advanced CKD stage, higher baseline systolic blood pressure and younger age were independently associated with WRF. Underlying cause of CKD, use of diuretics, use of renin angiotensin blockers, gender, and smoking status were not associated with WRF.Conclusion: In patients with stage 3 or higher CKD, Ramadan fasting during the summer months was associated with worsening of renal function. Clinicians need to warn CKD patients against Ramadan fasting.