@article {Aksoy156, author = {Asude Aksoy and Hatice Odabas and Serap Kaya and Oktay Bozkurt and Mustafa Degirmenci and Turkan O. Topcu and Ayd{\i}n Aytekin and Erkan Arpaci and Nilufer Avci and Kezban N. Pilanci and Havva Y. Cinkir and Yakup Bozkaya and Yalcin Cirak and Mahmut Gumus}, title = {Hormone receptor status and survival of medullary breast cancer patients}, volume = {38}, number = {2}, pages = {156--162}, year = {2017}, doi = {10.15537/smj.2017.2.18055}, publisher = {Saudi Medical Journal}, abstract = {Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC).Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis.Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5\% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4\% and overalll survival (OS) rate 95.7\%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p\<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p\<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p\>0.05).Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/38/2/156}, eprint = {https://smj.org.sa/content/38/2/156.full.pdf}, journal = {Saudi Medical Journal} }