PT  - JOURNAL ARTICLE
AU  - Aksoy, Asude
AU  - Odabas, Hatice
AU  - Kaya, Serap
AU  - Bozkurt, Oktay
AU  - Degirmenci, Mustafa
AU  - Topcu, Turkan O.
AU  - Aytekin, Aydın
AU  - Arpaci, Erkan
AU  - Avci, Nilufer
AU  - Pilanci, Kezban N.
AU  - Cinkir, Havva Y.
AU  - Bozkaya, Yakup
AU  - Cirak, Yalcin
AU  - Gumus, Mahmut
TI  - Hormone receptor status and survival of medullary breast cancer patients
AID  - 10.15537/smj.2017.2.18055
DP  - 2017 Feb 01
TA  - Saudi Medical Journal
PG  - 156--162
VI  - 38
IP  - 2
4099  - http://smj.org.sa/content/38/2/156.short
4100  - http://smj.org.sa/content/38/2/156.full
SO  - Saudi Med J2017 Feb 01; 38
AB  - Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC).Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis.Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p>0.05).Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.