RT Journal Article
SR Electronic
T1 Hormone receptor status and survival of medullary breast cancer patients
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 156
OP 162
DO 10.15537/smj.2017.2.18055
VO 38
IS 2
A1 Aksoy, Asude
A1 Odabas, Hatice
A1 Kaya, Serap
A1 Bozkurt, Oktay
A1 Degirmenci, Mustafa
A1 Topcu, Turkan O.
A1 Aytekin, Aydın
A1 Arpaci, Erkan
A1 Avci, Nilufer
A1 Pilanci, Kezban N.
A1 Cinkir, Havva Y.
A1 Bozkaya, Yakup
A1 Cirak, Yalcin
A1 Gumus, Mahmut
YR 2017
UL http://smj.org.sa/content/38/2/156.abstract
AB Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC).Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis.Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p>0.05).Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.