TY - JOUR T1 - Hormone receptor status and survival of medullary breast cancer patients JF - Saudi Medical Journal JO - Saudi Med J SP - 156 LP - 162 DO - 10.15537/smj.2017.2.18055 VL - 38 IS - 2 AU - Asude Aksoy AU - Hatice Odabas AU - Serap Kaya AU - Oktay Bozkurt AU - Mustafa Degirmenci AU - Turkan O. Topcu AU - Aydın Aytekin AU - Erkan Arpaci AU - Nilufer Avci AU - Kezban N. Pilanci AU - Havva Y. Cinkir AU - Yakup Bozkaya AU - Yalcin Cirak AU - Mahmut Gumus Y1 - 2017/02/01 UR - http://smj.org.sa/content/38/2/156.abstract N2 - Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC).Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uni- and multivariate cox regression analysis.Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p>0.05).Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates. ER -