RT Journal Article
SR Electronic
T1 Frequency of the exon 3-deleted/full-length growth hormone receptor polymorphism in Saudi Arabian population
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1090
OP 1095
DO 10.15537/smj.2017.11.21109
VO 38
IS 11
A1 Kaabi, Yahia A.
YR 2017
UL http://smj.org.sa/content/38/11/1090.abstract
AB Objectives: To investigate the frequency of the growth hormone receptor (GHR)-d3 polymorphism in a random sample of Saudi Arabian population from Jazan province, and test the effects of the polymorphism on some anthropometric factors.Methods: This cross-sectional population-based study was conducted during the period from January to April 2017 at the College of Applied Medical Sciences, Jazan University, Southwestern Saudi Arabia. A total of 230 healthy adult male and female volunteers were randomly recruited. Genomic DNA was extracted from the whole blood, and the GHR exon 3 locus was genotyped using multiplex polymerase chain reaction.Results: The distributions of the GHR genotypes were as follows: fl/fl (39.1%), fl/d3 (44.8%), and d3/d3 (16.1%). No statistically significant differences were found between fl/fl, fl/d3, or d3/d3 GHR genotypes in terms of weight (p=0.90), height (p=0.12), or body mass index (BMI) (p=0.83) values.Conclusion: No correlations were found between the GHR-d3 polymorphism and weight, height, or BMI.