RT Journal Article
SR Electronic
T1 Effect of gonadotropin-releasing hormone analogue on final adult height among Jordanian children with precocious puberty
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1101
OP 1107
DO 10.15537/smj.2017.11.21187
VO 38
IS 11
A1 Swaiss, Hala H.
A1 Khawaja, Nahla M.
A1 Farahid, Oraib H.
A1 Batieha, Anwar M.
A1 Ajlouni, Kamel M.
YR 2017
UL http://smj.org.sa/content/38/11/1101.abstract
AB Objectives: To study the effect of gonadotropin-releasing hormone analogue (GnRHa) on final adult height (FAH) among Jordanian children with central precocious puberty (CPP).Methods: It is a retrospective historical cohort study. We assessed the FAH and height gain in 43 children with CPP (39 females and 4 males) who received GnRHa and 13 children with CPP (11 females and 2 males) who did not receive GnRHa and achieved FAH between 2004 and 2014. Final adult height was compared to target height (TH) and mid- parental height (MPH) in both groups.Results: In GnRHa treated females, the FAH was 158.5±6.6 cm compared to 151.2±8.4 cm in the untreated females (p=0.004). Height gain was 2.9±8.5 cm in the treated females compared to -3.8±7.7 cm in the untreated group (p=0.022). In GnRHa treated females, FAH was found to be closer to TH (p=0.01) and MPH (p=0.01) in comparison to untreated females.Conclusion: Gonadotropin-releasing hormone analogue is effective in increasing FAH in Jordanian children with CPP, particularly those with advanced bone age.