RT Journal Article
SR Electronic
T1 Invasive Candidiasis in pediatric patients at King Fahad Medical City in Central Saudi Arabia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1118
OP 1124
DO 10.15537/smj.2017.11.21116
VO 38
IS 11
A1 Zainab Almoosa
A1 Gasmelseed Y. Ahmed
A1 Abeer Omran
A1 Ayah AlSarheed
A1 Afnan Alturki
A1 Abdulaziz Alaqeel
A1 Mohammed Alshehri
A1 Tariq Alfawaz
A1 Dayel Alshahrani
YR 2017
UL http://smj.org.sa/content/38/11/1118.abstract
AB Objectives: To identify predisposing factors, species distribution, antifungal susceptibility, and outcome.Methods: This study is a retrospective chart review that was conducted at a children’s hospital at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. One hundred twenty-nine children with invasive candidiasis who were admitted between January 2010 and January 2015.Results: The statistical analysis results have revealed a group of risk factors; prematurity in 37 (28.7%) of patients, low birth weight in 42 (32.6%), central venous catheter in 59 (45.7%), malignancy in 21 (16.3%), immunotherapy in 20 (15.5%), and ventilator support in 60 (46.5%). More than 2-fold mortality rate in patients who had heart vegetation (odds ratio [OR]: 2.9) and patients who had Candida isolated from their blood were more than twice as likely to die as patients with Candida isolated from other sites (OR: 2.2). A total of 48.3% of patients on ventilator died versus 26.1% who were not on ventilator (p=0.009); and 43.8% of patients in the ICU died versus only 24.5% of patients who were not in the ICU (p=0.03). Candida parapsilosis exhibited the highest mortality rate (56.2%).Conclusion: Candida albicans is the most common isolate among all Candida species. Gender, low birth weight, prolonged ICU stay, presence of vegetation, positive blood culture, and mechanical ventilation as a strong predictive risk factors for death in children with invasive candidiasis, a finding that could be applied as prophylactic indicator in critically ill children especially neonates.