RT Journal Article
SR Electronic
T1 Gastrointestinal stromal tumors
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 126
OP 130
DO 10.15537/smj.2019.2.23913
VO 40
IS 2
A1 Alghamdi, Hanan M.
A1 Amr, Samir S.
A1 Shawarby, Mohamed A.
A1 Sheikh, Salwa S.
A1 Alsayyah, Ahmed A.
A1 Alamri, Ali M.
A1 Ismail, Mona H.
A1 Almarhabi, Ahmed
A1 Alrefaee, Munir A.
A1 Ahmed, Muhammad I.
YR 2019
UL http://smj.org.sa/content/40/2/126.abstract
AB Objectives: To evaluate the clinical presentations and immunohistochemical (IHC) properties of gastrointestinal stromal tumors (GISTs) and to compare them to internationally published data.Methods: Thirty-six patients diagnosed with GISTs between January 1997 and December 2015 were retrospectively studied in 2 tertiary hospitals. Immunohistochemical staining was carried out prospectively when it has not been completed fully at the beginning.Results: The median age of patients was 54 years (range; 17-81 years). Predominantly, we found more females were affected. The male to female ratio was 1:1.7. The most frequently affected organs were the stomach (63.8%) followed by small bowel (25%) and colorectal region (8.4%). Abdominal pain was the most frequent presentation in 33.3% of the patients then gastrointestinal (GI) bleeding in 30.5%. Most of the gastric GISTs were at early stages at presentation: stage 1 and II (60.8%), while in non-gastric GISTs, the tumor stage was advanced: stage III and IV (69.3%). The IHC characteristic of GIST in descending order showed positivity for vimentin (88.9%), CD117 (83.3%), CD34 (77.8%), Ki67 (63.9%), SMA (38.9%), desmin (27.8%), and S100 (19.4%).Conclusion: Gastrointestinal stromal tumors in our study demonstrates a major similar feature as the published international data. However, minor differences do exist in terms of clinical features and immunohistochemistry.