RT Journal Article
SR Electronic
T1 Assessment of vancomycin utilization among Lebanese hospitals
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 152
OP 157
DO 10.15537/smj.2019.2.23872
VO 40
IS 2
A1 Diana N. Malaeb
A1 Iqbal M. Fahs
A1 Pascale Salameh
A1 Souheil Hallit
A1 Manal Saad
A1 Jassem Bourji
A1 Rabih Hallit
YR 2019
UL http://smj.org.sa/content/40/2/152.abstract
AB Objectives: To assess the appropriateness of vancomycin dosing and monitoring at Lebanese hospitals.Methods: This was a multicenter retrospective study conducted at 3 Lebanese hospitals between January and March 2018. Patients 18 years of age and older treated with vancomycin for a systemic infection or prophylaxis were eligible for study enrollment. Consistency with the Infectious Diseases Society of America guidelines was evaluated to determine whether the dose of vancomycin was appropriate, as well as for the time of trough measurement, and the target concentration obtained.Results: From a total of 120 patients who met the inclusion criteria, only 11 (12%) were given the appropriate maintenance dose of vancomycin with respect to actual body weight. The trough levels were monitored for 67 (55.8%) patients, with 20 (29.9%) of these patients achieving appropriate therapeutic trough levels of 15-20 mg/l. The trough concentration time measurement before the fourth dose was only carried out in 28 (41.8%) of the 67 patients.Conclusion: This study reveals a gap between the appropriate utilization of vancomycin with respect to the international guidelines in the studied Lebanese hospitals. It highlights the need for dosing and monitoring protocols suitable for vancomycin utilization in these hospitals.