PT  - JOURNAL ARTICLE
AU  - Alsagaby, Suliman A.
AU  - Alhumaydhi, Fahad A.
TI  - Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
AID  - 10.15537/smj.2019.4.23598
DP  - 2019 Apr 01
TA  - Saudi Medical Journal
PG  - 317--327
VI  - 40
IP  - 4
4099  - http://smj.org.sa/content/40/4/317.short
4100  - http://smj.org.sa/content/40/4/317.full
SO  - Saudi Med J2019 Apr 01; 40
AB  - Chronic lymphocytic leukemia (CLL) is an incurable malignant disease of B-lymphocytes characterized by drastically heterogeneous clinical courses. Proteomics is an advanced approach that allows a global profiling of protein expression, providing a valuable chance for the discovery of disease-related proteins. In the last 2 decades, several proteomics studies were conducted on CLL to identify aberrant protein expression underpinning the malignant transformation and progression of the disease. Overall, these studies provided insights into the pathology and prognosis of CLL and reveal protein candidates with the potential to serve as biomarkers and/or therapeutic targets of the tumor. The major findings reported in these studies are discussed here.