RT Journal Article
SR Electronic
T1 Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 317
OP 327
DO 10.15537/smj.2019.4.23598
VO 40
IS 4
A1 Suliman A. Alsagaby
A1 Fahad A. Alhumaydhi
YR 2019
UL http://smj.org.sa/content/40/4/317.abstract
AB Chronic lymphocytic leukemia (CLL) is an incurable malignant disease of B-lymphocytes characterized by drastically heterogeneous clinical courses. Proteomics is an advanced approach that allows a global profiling of protein expression, providing a valuable chance for the discovery of disease-related proteins. In the last 2 decades, several proteomics studies were conducted on CLL to identify aberrant protein expression underpinning the malignant transformation and progression of the disease. Overall, these studies provided insights into the pathology and prognosis of CLL and reveal protein candidates with the potential to serve as biomarkers and/or therapeutic targets of the tumor. The major findings reported in these studies are discussed here.