PT  - JOURNAL ARTICLE
AU  - Semra Eroglu
AU  - Gulsah Karatas
TI  - Platelet/lymphocyte ratio is an independent predictor for osteoporosis
AID  - 10.15537/smj.2019.4.24009
DP  - 2019 Apr 01
TA  - Saudi Medical Journal
PG  - 360--366
VI  - 40
IP  - 4
4099  - http://smj.org.sa/content/40/4/360.short
4100  - http://smj.org.sa/content/40/4/360.full
SO  - Saudi Med J2019 Apr 01; 40
AB  - Objectives: To investigate the intercourse between the platelet/lymphocyte (P/L) and neutrophil/lymphocyte ratio (N/L), and vitamin D (Vit-D) levels in low bone mineral density (BMD) of women.Methods: Two hundred fifty-two postmenopausal female outpatients who were admitted to the obstetrics and gynecology and physical therapy clinics between July 2016 and December 2017 were retrospectively analyzed. The patients were grouped in relation to their T-score (normal [n=92], osteopenia [n=112], and PMO [n=48]). The serum levels of P/L, N/L, Vit-D, BMD and complete blood count of the patients were retrospectively examined.Results: The median P/L was significantly higher and Vit-D levels were significantly lower in the PMO group (130.75 [52.89-385] versus 123.05 [54-232.5], p=0.02 and 15.4 [4-34] versus 20.1 [4-47], p=0.003). While BMD and P/L were negatively correlated, a positive correlation between BMD and Vit-D was found. Vitamin D levels were negatively correlated with P/L (p<0.001) and N/L (p=0.04). Older age (≥65 years), Vit-D deficiency and P/L values >125.06 were found as independent prognostic factors for PMO in regression analysis.Conclusion: Higher P/L seems to be a quite simple marker to help predict postmenopausal PMO. As seen in our study, having low levels of Vit-D is crucial for PMO.