RT Journal Article
SR Electronic
T1 Analysis of drug resistance of extended-spectrum beta-lactamases-producing <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em> in children with urinary tract infection
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1111
OP 1115
DO 10.15537/smj.2019.11.24547
VO 40
IS 11
A1 Keshi, Lu
A1 Weiwei, Xiao
A1 Shoulin, Li
A1 Xiaodong, Liu
A1 Hao, Wang
A1 Junhai, Jiang
A1 Xiangwei, Wang
A1 Rui, Wang
A1 Pei, Zhu
YR 2019
UL http://smj.org.sa/content/40/11/1111.abstract
AB Objectives: To investigate the drug resistance of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K.pneumoniae) in children with urinary tract infection (UTI) and to provide the rationale for clinical use of antibiotics.Methods: This is a retrospective analysis of drug susceptibility in children with E. coli or K. pneumoniae-positive urine culture between August 2013 and August 2017, Shenzhen Children’s Hospital, Shenzhen, China. Drug resistance was statistically assessed using Fisher exact test and χ2 test.Results: A total of 698 cases of E. coli, 426 of which were confirmed ESBL-producing strains, and 217 cases of K. pneumoniae, including 111 ESBL-producing strains, were detected, and the difference in proportion of positive ESBL-producing strains (61.03% versus 51.15%) was statistically significant (p=0.010). The average drug resistance rates of E. coli and K. pneumoniae to piperacillin/tazobactam, meropenem, ertapenem, imipenem, and amikacin were &lt;15%. The average resistance rates of ESBL-producing E. coli and K. pneumoniae to cefpodoxime, cefixime, cefazolin, and ceftriaxone was &gt;98%, while average resistance rates for non-ESBL-producing bacteria to the above 4 drugs was &lt;20%.Conclusion: In southern China, the proportion of ESBL-producing strains and the drug resistance rates of E. coli and K. pneumoniae in UTI in children was high, but their resistance rates to carbapenems and β-lactamase inhibitor complexes containing tazobactam were low. Carbapenems are the most effective antibacterial drugs for the treatment of ESBL-producing bacteria.