RT Journal Article
SR Electronic
T1 Overall survival of adult acute myeloid leukemia based on cytogenetic and molecular abnormalities during 5 years in a single center study
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1171
OP 1176
DO 10.15537/smj.2019.11.24584
VO 40
IS 11
A1 Alsobhi, Enaam M.
A1 Farahat, Fayssal M.
A1 Daghistani, Mustafa F.
A1 Awad, Khadeeja A.
A1 Al-Zahrani, Omar S.
A1 Al-Saiari, Afaf S.
A1 Koshak, Fai K.
YR 2019
UL http://smj.org.sa/content/40/11/1171.abstract
AB Objectives: To determined the 5-year overall survival (OS) rates for adult patients with acute myeloid leukemia (AML) patients at King Abdulaziz Medical City, Jeddah, Saudi Arabia, based on cytogenetic and molecular abnormalities.Methods: A retrospective cohort study reviewing adult AML patient files between 2011 and 2018. Sixty-three patients were excluded due to pediatric age and secondary AML. The remaining 87 adult patients with de novo AML were enrolled in this study.Results: The most frequent cytogenetic abnormalities were t(15;17) (17.2%), followed by complex cytogenetic (13.8%) and t(8;21) (5.7%). The most frequent molecular abnormalities were promyelocytic leukemia/retinoic acid receptor alpha (PML-RARA) (16.1%) and Nucleophosmin 1 (NPM1) (11.5%). The highest OS rate was associated with t(15;17), PML-RARA, and NPM. However, complex cytogenetic was associated with the lowest OS rate; fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication was independently correlated with low OS rate.Conclusion: The study describes cytogenetic and molecular abnormalities observed in adult AML patients and gives an overview of prognostic factors and determine the OS, with comparable results with recent published data by the WHO.