PT  - JOURNAL ARTICLE
AU  - Tao, Haitao
AU  - Li, Fangfang
AU  - Wang, Jinliang
AU  - Dong, Weiwei
AU  - Gao, Jie
AU  - Jiao, Shunchang
AU  - Hu, Yi
TI  - Management of treatment-naïve limited-stage small cell esophagus carcinoma
AID  - 10.15537/smj.2015.3.11368
DP  - 2015 Mar 01
TA  - Saudi Medical Journal
PG  - 297--303
VI  - 36
IP  - 3
4099  - http://smj.org.sa/content/36/3/297.short
4100  - http://smj.org.sa/content/36/3/297.full
SO  - Saudi Med J2015 Mar 01; 36
AB  - Objectives: To identify the problems and principles of treatment decisions in treatment-naïve limited-stage small cell esophagus carcinoma (LD-SCEC).Methods: Clinical data from 39 patients with LD-SCEC treated in the Chinese People’s Liberation Army General Hospital, Beijing, China between 2000 and 2013 were retrospectively collected with regard to pathologic characteristics, overall survival (OS), and relevant prognostic factors.Results: The median OS was 21.1 months (95% confidence interval [CI]: 12.4-29.7 months). The one-year OS was 76%, 3-year was 25%, and the 5-year OS was 8%. Depth of invasion, lymph metastasis status, and chemotherapy were independent prognostic factors. Of the 39 cases, only 38.4% (15 cases) were diagnosed as SCEC by the biopsy specimen. Eight of the 15 patients (group A) received chemotherapy and/or radiotherapy, while the remaining 7 patients (group B) and the other 24 patients (group C) received surgery as initial treatment. The one-year survival of group A was 87%, of group B was 69%, and of group C was 74% (p=0.037). The accuracy of the biopsy diagnosis influenced the treatment decisions and prognosis.Conclusion: Small cell esophagus carcinoma is a systemic disease, with depth of invasion, lymph metastasis status, and chemotherapy as independent prognostic factors. Systemic therapy based on chemotherapy is recommended. The top priority is to improve the accuracy of diagnosis before deciding on the initial treatment option.