PT  - JOURNAL ARTICLE
AU  - Yilmaz, Omer
AU  - Nese, Nalan
AU  - Dalgic, Mustafa
AU  - Kesici, Gonca P.
AU  - Genc, Abdulkadir
AU  - Taneli, Can
AU  - Gunsar, Cuneyt
AU  - Sencan, Aydın
AU  - Cayirli, Hasan
AU  - Isisag, Aydın
TI  - Sonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction
AID  - 10.15537/smj.2016.7.14789
DP  - 2016 Jul 01
TA  - Saudi Medical Journal
PG  - 737--743
VI  - 37
IP  - 7
4099  - http://smj.org.sa/content/37/7/737.short
4100  - http://smj.org.sa/content/37/7/737.full
SO  - Saudi Med J2016 Jul 01; 37
AB  - Objectives: To compare pathological samples obtained from cases that underwent surgery for ureteropelvic junction (UPJ) obstruction with samples obtained during autopsies of subjects.Methods: Retrospectively, 42 patients who had undergone surgery due to UPJ obstruction (group 1) were included in the study. Histopathological and immunohistochemical features for sonic hedgehog (SHH), TBX18, and TSHZ3 of UPJ were evaluated and findings were compared with 20 autopsy cases (group 2).Results: In group 1, the scores were statistically significantly higher in terms of cytoplasmic SHH, nuclear TBX18, cytoplasmic and nuclear TSHZ3 staining. Statistically, no correlation was found between age and the staining scores belonging to these 3 antibodies in group 1 and group 2. Intense inflammation was found to be related with nuclear staining for TBX18.Conclusion: Gene product expressions of SHH, TBX18 and TSHZ3 are statistically higher in patients with UPJ obstruction, when compared with control group. The explanation may be the reactivation of the processes, which had shown their effects in the embryological period, due to the chronic inflammation and long-term micro-trauma created by the disease.