RT Journal Article
SR Electronic
T1 Sonic hedgehog, TBX18, and TSHZ3 proteins involved in pyeloureteral motility development are overexpressed in ureteropelvic junction obstruction
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 737
OP 743
DO 10.15537/smj.2016.7.14789
VO 37
IS 7
A1 Yilmaz, Omer
A1 Nese, Nalan
A1 Dalgic, Mustafa
A1 Kesici, Gonca P.
A1 Genc, Abdulkadir
A1 Taneli, Can
A1 Gunsar, Cuneyt
A1 Sencan, Aydın
A1 Cayirli, Hasan
A1 Isisag, Aydın
YR 2016
UL http://smj.org.sa/content/37/7/737.abstract
AB Objectives: To compare pathological samples obtained from cases that underwent surgery for ureteropelvic junction (UPJ) obstruction with samples obtained during autopsies of subjects.Methods: Retrospectively, 42 patients who had undergone surgery due to UPJ obstruction (group 1) were included in the study. Histopathological and immunohistochemical features for sonic hedgehog (SHH), TBX18, and TSHZ3 of UPJ were evaluated and findings were compared with 20 autopsy cases (group 2).Results: In group 1, the scores were statistically significantly higher in terms of cytoplasmic SHH, nuclear TBX18, cytoplasmic and nuclear TSHZ3 staining. Statistically, no correlation was found between age and the staining scores belonging to these 3 antibodies in group 1 and group 2. Intense inflammation was found to be related with nuclear staining for TBX18.Conclusion: Gene product expressions of SHH, TBX18 and TSHZ3 are statistically higher in patients with UPJ obstruction, when compared with control group. The explanation may be the reactivation of the processes, which had shown their effects in the embryological period, due to the chronic inflammation and long-term micro-trauma created by the disease.