PT  - JOURNAL ARTICLE
AU  - Sadat-Ali, Mir
AU  - Al-Turki, Haifa A.
AU  - Azam, Mohammed Q.
AU  - Al-Elq, Abdulmohsen H.
TI  - Genetic influence on circulating vitamin D among Saudi Arabians
AID  - 10.15537/smj.2016.9.14700
DP  - 2016 Sep 01
TA  - Saudi Medical Journal
PG  - 996--1001
VI  - 37
IP  - 9
4099  - http://smj.org.sa/content/37/9/996.short
4100  - http://smj.org.sa/content/37/9/996.full
SO  - Saudi Med J2016 Sep 01; 37
AB  - Objectives To examine the effect of most common studied single nucleotide polymorphisms (SNP) on serum 25-hydroxyvitamin D (25OHD) levels in Saudi Arabian population.Method A cross-sectional observational study was carried out between July 2014 and October 2015, at King Fahd Hospital of the University (KFHU), Al-Khobar, Kingdom of Saudi Arabia. After informed consent, blood samples from 283 subjects living in the Eastern province were collected for 25-OHD measurement and genetic analysis of SNPs in vitamin D receptor (VDR) [rs2228570 and rs1544410], Cytochrome, P450 family 2 (CYP2R1) [rs10741657 and rs1993116], and Group-specific components (GC) [rs2282679 and rs4588].Results Vitamin D deficiency was found in 87.6% and insufficiency in 7.7%. The percentages of the different alleles of the 6 SNPs tested ranged between 0-62.5%. There was significant difference between the AA, AG, and GG alleles of VDR rs2228570. The carries of GG allele was associated with increased risks of vitamin D insufficiency (p<0.002) and deficiency (p≤0.005). The CYP2R1 rs10741657 gene showed that AG and GG allele carriers had significant risk of vitamin D deficiency. AG allele (normal versus Insufficiency p<0.02 and normal versus deficiency p<0.08) and GG allele normal versus deficiency (p<0.002) and insufficiency versus deficiency (p<0.001). For group-specific components (GC rs4588), there was only significant difference between the normal and deficiency for the AC allele (p<0.0001).Conclusion The presence of GG allele of the SNP rs2228570 of VDR gene, SNPs rs4588 of GC gene and CYP2R1 rs10741657 gene was associated with vitamin D deficiency.